CytoPure™ PLUS
Best for routine research
Fibrinogen-depleted human platelet lysate with heparin included — a high-performance, direct replacement for FBS in routine MSC and primary cell culture.
Human Platelet Lysate
Human Platelet Lysate Designed for Reliable Cell Expansion
In primary human MSC culture, 5% CytoPure™ XF delivered 1.8× the population doublings of 10% FBS — at half the supplement concentration. Fibrinogen-depleted, xeno-free, and manufactured in the USA.
Fibrinogen-Depleted Formulations
Xeno-Free Options
Manufactured in the USA
Quality Tested Every Lot
Product Family
Which CytoPure™ Is Right for You?
Start with your application, not a catalog. Every CytoPure™ formulation is fibrinogen-depleted for clot-free culture — choose the grade that matches your workflow.
Most popular
CytoPure™ XF
Best for xeno-free workflows
Fibrinogen-depleted and xeno-free with no supplemental heparin required — formulated for media preparation aligned with translational and cell therapy pathways.
CytoPure™ GI
Best for added risk mitigation
Gamma-irradiated, fibrinogen-depleted, and xeno-free — adding a pathogen risk-mitigation step for applications and workflows that require it.
At a Glance
Compare the CytoPure™ family
All three are fibrinogen-depleted. Choose based on heparin, xeno-free status, and whether you need gamma irradiation.
| Attribute | CytoPure™ PLUS | CytoPure™ XF | CytoPure™ GI |
|---|---|---|---|
| Fibrinogen-depleted | Yes | Yes | Yes |
| Xeno-free | No — contains heparin | Yes | Yes |
| Supplemental heparin required | None — fibrinogen-depleted | None — not required | None — not required |
| Gamma-irradiated | No | No | Yes |
| Best for | Low-risk applications | Higher performance Pre-clinical Research |
Added risk mitigation |
| Learn more | CytoPure™ PLUS | CytoPure™ XF | CytoPure™ GI |
The Science
Why Human Platelet Lysate?
Human platelet lysate replaces fetal bovine serum with a human-derived supplement rich in native growth factors — improving reproducibility and aligning culture with the requirements of human-use therapies.
Fetal Bovine Serum (FBS)
- Animal-derived and xenogeneic
- Significant lot-to-lot variability
- Ethical and supply-chain concerns
- Regulatory friction for human-use therapies
CytoPure™ Human Platelet Lysate
- Human-derived, with xeno-free options
- Rich in native human growth factors
- Reproducible, defined performance
- Fibrinogen-depleted — no clotting in culture
Why CytoPure™
Engineered for Performance and Trust
These aren't just product features — they're reasons to build your process on Cytologics.
Fibrinogen-Depleted Technology
Eliminates clotting in culture without supplemental heparin, keeping your media clear and consistent.
High Growth Factor Content
Rich in the native human growth factors that drive robust proliferation and expansion.
Human-Derived
A human platelet source that fits xeno-free and clinically oriented workflows.
Rigorous Quality Testing
Every lot is tested and released against defined specifications, with a Certificate of Analysis.
U.S.-Manufactured from FDA/AABB Platelets
Made in the USA from human platelet units sourced through FDA-licensed, AABB-accredited U.S. blood centers.
Responsive Technical Support
Direct access to the scientists who make the product — not an outsourced call center.
Applications
Used Across Demanding Primary Cell Types
Our full performance data — growth, doubling time, phenotype — is in primary human mesenchymal stromal cells. For other cell types we publish the starting concentrations reported in the human platelet lysate literature, with citations, so you can narrow a titration rather than guess at one.
Performance
Consistent Expansion, Lot After Lot
Primary human mesenchymal stromal cells, expanded in 5% CytoPure™ XF against a 10% FBS control — the same experiment run across five independent lots.
20.6
Population doublings at day 50 in 5% CytoPure™ XF — against 11.4 in 10% FBS
26.2 h
hUC-MSC doubling time in 5% CytoPure™ XF — against 35.8 h in 10% FBS
17.6–21.5
Population doublings at day 50 across five independent CytoPure™ XF lots — the 10% FBS range was 8.9–11.4, with no overlap
Research Use Only. Data generated by Cytologics in primary human mesenchymal stromal cell culture. Expansion kinetics in other cell types have not been characterized — see Applications.
Quality & Compliance
Sourcing and quality you can document
Human platelet units are collected at our FDA-licensed, AABB-accredited U.S. blood-center network operating under GMP standards, then manufactured under a rigorous quality management system.
Per-lot COApH, osmolality, protein, sterility, mycoplasma, endotoxin
Every lot has to grow cellsPrimary human cell proliferation, verified at release
21 CFR 610 donor testingHIV, HBV, HCV, HTLV, Syphilis, WNV
FDA-licensed, AABB-accreditedU.S. blood-center sourcing
Technical Resources
Sixteen controlled documents, not a folder of PDFs
Every document carries a number, a revision and an effective date, so your quality group can cite the one they reviewed. These three are the most asked for.
Free Evaluation
Try CytoPure™ XF Free
Request a complimentary 30 mL evaluation sample and see the difference in your own culture system. Tell us a little about your application and our team will follow up.
- 30 mL of CytoPure™ XF, xeno-free hPL
- Certificate of Analysis included
- No obligation
Two minutes
Request your free sample
Tell us your application and where to ship it. Samples go out frozen, on dry ice, with the lot's Certificate of Analysis.
No obligation. Research Use Only.