A naïve CD3+ T cell is a mature T cell that has differentiated in the bone marrow. Unlike memory CD3+ T cells, naïve CD3+ T cells have not acquired an activated phenotype, therefore naïve CD3+ T cells can respond to unfamiliar pathogens that have not been previously encountered and initiate an immune response. As a result, these naïve T cells can acquire the phenotype and ultimately differentiate into a memory T cell.
Naïve CD3+ T cells
Our naïve CD3+ T cells are collected at FDA-licensed donor centers and further processed at our cell isolation laboratory. Naïve T cells are isolated by depleting CD45RO+ cells from PBMCs by negative selection using immunomagnetic cell separation procedures. Naïve T cells are phenotypically classified as CD45+, CD3+, and CD45RA+. All donors are tested for HIV, Hepatitis B and C, WNV, CMV, and other blood-borne pathogens.
All biospecimens are obtained from properly consented donors. We conform to HIPAA standards to protect the privacy of the donor’s personal health information.
Human Material Precaution
It is best to use caution when handling any human cells. We recommend all human cells should be handled as if potentially infectious following biosafety level 2 procedures.
Even with infectious virus assays or viral antigen assays, a negative test result may leave open the possible existence of latent viruses.