Naïve CD4 T cells have differentiated from bone marrow, and have successfully undergone the central tolerance processes of positive and negative selection in the thymus. They are considered mature but inactivated, responding to novel pathogens in the immune system and initiate the immune response. They are used to elicit brand new immune responses in in vitro and in vivo studies.
Naïve CD4+ T cells
Our naïve CD4+ T cells are collected at FDA-licensed donor centers and further processed at our cell isolation laboratory. Naïve CD4+ T cells are isolated from PBMCs using negative immunomagnetic cell separation procedures; positive selection is also available at your request. Each product is characterized by flow cytometry to ensure a highly pure and viable cell population. All donors are tested for HIV, Hepatitis B and C, WNV, CMV, and other blood-borne pathogens.
All biospecimens are obtained from properly consented donors. We conform to HIPAA standards to protect the privacy of the donor’s personal health information.
Human Material Precaution
It is best to use caution when handling any human cells. We recommend all human cells should be handled as if potentially infectious following biosafety level 2 procedures.
Even with infectious virus assays or viral antigen assays, a negative test result may leave open the possible existence of latent viruses.